NCBI PubChem BioAssay Database

NCBI’s PubChem BioAssay database (1-5) (http://pubchem.ncbi.nlm.nih.gov) is a public repository for archiving biological tests of small molecules and siRNA reagents. Small molecule bioactivity data contained in the BioAssay database consist of information generated through high-throughput screening experiments, medicinal chemistry studies, chemical biology research, as well as literature curation. In addition, the BioAssay database contains data from RNAi screens against targeted genes or complete genomes aiming to identify critical genes responsible for a biological process or disease condition. BioAssay data continue to grow rapidly and are integrated with the rest of the NCBI resources, making PubChem a widely used public information system for accelerating chemical biology research and drug development.